AREDS 2 Formula Study
This page provides a summary of the Age-Related Eye Disease Study 2 (AREDS 2) conducted by the National Eye Institute (NEI). This study investigated the potential benefits of dietary supplements in slowing the progression of age-related macular degeneration (AMD).
Key Findings of the AREDS 2 Study:
- The original AREDS formula (vitamin C, vitamin E, beta-carotene, zinc, and copper) significantly reduced the risk of advanced AMD.
- The AREDS 2 study aimed to improve the original formula by investigating the effects of lutein and zeaxanthin, and by removing beta-carotene due to concerns about lung cancer risk in smokers.
- The AREDS 2 formula, which contains lutein and zeaxanthin instead of beta-carotene, was shown to be effective and safer for smokers and former smokers.
- Removing beta-carotene and/or adding lutein and zeaxanthin did *not* significantly improve outcomes compared to the original AREDS formula for those who never smoked.
- The addition of omega-3 fatty acids (DHA and EPA) to the AREDS formula did *not* significantly improve outcomes.
- Lowering the zinc dosage (from 80mg to 25mg) did *not* significantly affect outcomes and may be preferable for some individuals to reduce potential side effects.
The Recommended AREDS 2 Formula:
Based on the AREDS 2 study results, the recommended formula is:
| Nutrient | Dosage |
|---|---|
| Vitamin C | 500 mg |
| Vitamin E | 400 IU |
| Lutein | 10 mg |
| Zeaxanthin | 2 mg |
| Zinc | 25 mg |
| Copper | 2 mg (to prevent copper deficiency due to high zinc intake) |
Important Considerations:
- Consult with your ophthalmologist or healthcare provider before starting any dietary supplement regimen, including the AREDS 2 formula. They can assess your individual risk factors, potential drug interactions, and recommend the appropriate dosage.
- The AREDS 2 formula is intended to slow the progression of AMD; it is not a cure and will not restore lost vision.
- Individuals with other medical conditions or taking other medications should be particularly cautious and consult with their doctor.
- The AREDS 2 formula is typically recommended for individuals with intermediate or advanced AMD. It is not generally recommended for those with early AMD or no AMD.
- Be aware that some commercially available AREDS 2 supplements may contain different formulations or dosages than those used in the original study. Carefully read the product label and consult with your doctor if you have any questions.
Disclaimer: This information is for general knowledge and informational purposes only, and does not constitute medical advice. It is essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.